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The Vitamin B12 (Cyanocobalamin) test measures the level of Vitamin B12 — an essential water-soluble vitamin — in the blood. B1...
Also known as: Serum B12 Test · Cobalamin Test · Vitamin B12 Level Test · Cyanocobalamin Test · B12 Deficiency Test
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*Inclusive of home collection charges
The Vitamin B12 (Cyanocobalamin) test measures the level of Vitamin B12 — an essential water-soluble vitamin — in the blood. B12 is critical for red blood cell formation, DNA synthesis, myelin sheath production (insulating nerve fibres), and neurological function. Deficiency causes macrocytic megaloblastic anaemia and — critically — irreversible neurological damage if untreated. B12 deficiency is extremely common in India, particularly among vegetarians and vegans, the elderly, and individuals on long-term antacid or metformin therapy. No fasting required.
Key benefits of this package include:
What Does the Vitamin B12 (Cyanocobalamin) Test Measure?
| Level / Result | Possible Interpretation |
|---|---|
| < 200 pg/mL (Deficient) | Significant B12 deficiency — supplementation required; neurological assessment if symptomatic |
| 200–300 pg/mL (Borderline / Low-normal) | Functional deficiency likely in symptomatic patients — treat empirically; confirm with MMA or homocysteine if needed |
| 300–400 pg/mL (Low-normal) | Adequate for most functions but suboptimal for neurological protection — review diet and absorption |
| 400–900 pg/mL (Normal / Optimal) | Adequate Vitamin B12 status |
| > 900 pg/mL (Elevated) | May occur with liver disease (hepatic B12 release), myeloproliferative disorders, or excessive supplementation — clinical context required |
Important Note: Serum B12 is a total B12 measurement and does not distinguish between active and inactive B12 forms. Up to 20–30% of patients with low-normal B12 (200–400 pg/mL) have functional B12 deficiency detectable only through elevated methylmalonic acid (MMA) or homocysteine. In symptomatic patients with borderline B12, these additional tests or empirical supplementation may be appropriate. All results must be reviewed by a physician.
B12 Deficiency and Neurological Damage — Act Before Symptoms Progress: The neurological complications of B12 deficiency — subacute combined degeneration of the spinal cord (SACD), peripheral neuropathy, optic atrophy — can be irreversible if treatment is delayed. SACD causes progressive loss of proprioception (position sense), balance, and strength — starting with tingling and numbness in the feet and hands, progressing to weakness and spastic gait. Unlike the anaemia of B12 deficiency (which responds fully to treatment), neurological damage may only partially recover. This is why early testing and treatment — before neurological symptoms appear — is the most important preventive measure.
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